adolescence

To Diagnose or Not to Diagnose: The Debate on Personality Disorders in Adolescence

The Intersectionality of PD in Adolescence 

The presentation of a personality disorder in adolescence is complicated by the ongoing debate of whether personality disorders should be diagnosed. Some licensed health professionals are hesitant to provide a diagnosis due to the belief that adolescence is a period of changing personality,[1] thus, it is not appropriate to judge if a personality is disordered. However, other health professionals argue for the benefits of early detection and treatment, leading to better health outcomes.[2] The impacts of the home environment, genetics and consequences of a diagnosis further complicate this debate.

Effects of Home Environment 

Childhood maltreatment (e.g., neglect, physical abuse) substantially increases the risk of developing a personality disorder.[3] The Minnesota Project by Sroufe et al. (2005) followed a group of high-risk children into adulthood and found that insecure attachment during childhood is strongly associated with the later development of personality disorders in adolescence.[4] Later studies on Borderline Personality Disorders (BPD) further supported the association of adverse childhood experiences as a risk factor for personality disorders. Marchetti et al. (2022) found that a history of childhood maltreatment was associated with higher levels of BPD in adolescents (average age 16).[5] Furthermore, studies by Xiao et al. (2023) found that adolescents with BPD had higher rates of all the assessed childhood traumas when compared to adolescents with non-disordered personalities; this was especially true for emotional neglect (the most commonly seen childhood trauma).[6]

Effects of Biological Factors

Adolescence is a time of biological change, including those that regulate one’s personality. Throughout adolescence, the brain continues to develop in term of myelination and the formation of synaptic networks; thus, the neural basis for many psychological regulatory systems are still in development.[7] Furthermore, the frontal, temporal and occipital lobes of the brain (which are responsible for response inhibition, emotion regulation, planning and organization) are still developing during adolescence, which may account for the increased impulsivity sometimes seen during this period.[8] The increased levels of sex hormones adolescents are exposed to during puberty also affect mood regulation.[9] Therefore, the developmental changes of adolescence can bring forth impulsivity and mood changes, similar to the changes brought by a personality disorder. 

However, studies by Xiao et al. (2023) have found that there are also biological differences in adolescents with personality disorders compared to non-disordered peers.[10] They found that adolescents with Borderline Personality Disorder showed increased Amplitude Low-Frequency Fluctuations in the limbic system (a measure of spontaneous neuronal activity related to the mood swings associated with BPD).[11] Thus, biological factors can also account for differences in the mood swings of adolescents with disordered personalities compared to non-disordered adolescents.

Arguments in favor of a diagnosis

The argument in favor of a diagnosis appeals to the benefits of early diagnosis, specifically: better health outcomes. Paris et al. (2013) report that conditions such as antisocial personality disorders begin in childhood, and as a result of the early onset, psychopathology is more likely to continue.[12] An analysis of personality trait dimensions also supports the early establishment of personality. Studies by Shiner et al. (2009) suggest a continuity from child to adult personality based on findings that certain personality traits (e.g., openness, conscientiousness, extroversion, agreeableness, neuroticism) in childhood predicted later behaviors.[13] Klimstra et al. (2009) distinguish that personality traits change considerably at the ages of 10-15 years old and then stabilize at the ages of 16-21 years.[14] However, according to Cicchetti et al. (2009), since personality disorders (PD) do not begin in adulthood, early investigation is necessary to develop a lifespan model for treatment.[15] Schmeck (2022) further supports the need for early intervention in personality disorders, arguing that early diagnosis rids the stigma associated with PD and lessens the possibility of long-lasting impairments and disability by facilitating the transition into adulthood.[16] 

These benefits of early diagnosis may have been considered by the Diagnostic and Statistical Manual of Mental Disorders (DSM) since the most recent version of the guide to diagnosing mental disorders has changed its age requirements for diagnosing PD. While earlier versions of the DSM did not allow someone under 18 to be diagnosed, the DSM-5 (the most recent version) allows the diagnosis of a personality disorder in someone under 18 if symptoms are present for at least one year.[17] 

Arguments against diagnosis

A study by Laurenssen et al. (2013) found that 57.8% of psychologists working with adolescents acknowledged the existence of personality disorders in this age group; however, only 8.7% of them actually made formal PD diagnoses in the adolescents.[18] The majority of psychologists are reluctant to diagnose adolescents based on the idea that personality is fluid and still developing.[19] Dijk et al. (2021) argue that while personality traits (e.g., openness, conscientiousness, extroversion, agreeableness, neuroticism) are structurally similar between adolescents and adults, there are developmental differences; for example, adolescents appear to be less conscientious.[20] Some psychologists also argue that an early diagnosis is stigmatizing since personality pathology can often be viewed as being unmodifiable.[21,22] Furthermore, according to Adshead et al. (2012), a misdiagnosis of a personality disorder in adolescence can focus attention away from interventions to improve the caregiving environment, particularly if neglect or abuse are present.[23] Perhaps taking the drawbacks of diagnosis into account, the American Psychiatric Association webpage, as of now, states that diagnosis of personality disorders is only applicable to individuals 18 and older (It is important to note that the American Psychiatric Association oversees the DSM-5).[24]

Treatment of PD in adolescence

Personality disorders vary in the ways they impact an individual’s thoughts and ways of expressing themselves, however, they align in their need for treatment to go away.[25] In adults certain psychotherapies (e.g., Dialectical Behavior Therapy (DBT), Cognitive Behavioral Therapy (CBT), Group Therapy, Psychoanalytic) have shown to be effective for treating personality disorder.[26] If an adolescent is diagnosed with a personality disorder, their treatment plans may differ slightly from adults. Adolescent treatment plans are complex due to a current need for more evidence if adult interventions also work for adolescents.[27] Furthermore, these treatment plans are unique as they often incorporate the adolescent’s school and parents.[28]

If you believe you or your child may have a personality disorder, please reach out to a licensed mental health professional (e.g., a psychotherapist, psychologist or psychiatrist) for guidance and support.

Contributed by: Maria Karla Bermudez

Editor: Jennifer (Ghahari) Smith, Ph.D.

References

1 Adshead, G., Brodrick, P., Preston, J., & Deshpande, M. (2012). Personality disorder in adolescence. Advances in Psychiatric Treatment, 18(2), 109-118. doi:10.1192/apt.bp.110.008623

2 Cicchetti, D., & Crick, N. R. (2009). Precursors and diverse pathways to personality disorder in children and adolescents. Development and Psychopathology, 21(3), 683-685. doi:https://doi.org/10.1017/S0954579409000388

3 Adshead et al. (2012)

4 Sroufe, A, Egeland, B, Carlson, E et al (2005) The Development of the Person: The Minnesota Study of Risk and Adaptation from Birth to Adulthood. Guilford Press

5 Marchetti, D., Musso, P., Verrocchio, M., Manna, G., Kopala-Sibley, D., De Berardis, D., . . . Falgares, G. (2022). Childhood maltreatment, personality vulnerability profiles, and borderline personality disorder symptoms in adolescents. Development and Psychopathology, 34(3), 1163-1176. doi:10.1017/S0954579420002151

6 Xiao, Q., Yi, X., Fu, Y., Jiang, F., Zhang, Z., Huang, Q., Han, Z., & Chen, B. T. (2023). Altered brain activity and childhood trauma in Chinese adolescents with borderline personality disorder. Journal of affective disorders, 323, 435–443. https://doi.org/10.1016/j.jad.2022.12.003

7 Adshead et al. (2012)

8 Ibid. 

9 Ibid. 

10 Xiao et al. (2023)

11 Ibid. 

12 Paris, Joel. “Personality disorders begin in adolescence.” Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent vol. 22,3 (2013): 195-6. doi:10.1007/s00787-013-0389-7

13 Shiner, R (2009) The development of personality disorders: perspectives from normal development. Development and Psychopathology 4: 715–34

14 Klimstra, TA, Hale, WW, Raaijmoken, QA (2009) Maturation of personality in adolescence. Journal of Personality, Society & Psychology 96: 898–912

15 Cicchetti et al. (2009)

16 Schmeck, K. (2022, March 17). Debate: Should CAMHS professionals be diagnosing ... - wiley online library. ACAMH. https://acamh.onlinelibrary.wiley.com/doi/10.1111/camh.12553

17 Personality disorders: Diagnosis. CAMH. (n.d.). https://www.camh.ca/en/professionals/treating-conditions-and-disorders/personality-disorders/personality-disorders---diagnosis#:~:text=According%20to%20DSM%2D5%2C%20features,for%20at%20least%20one%20year.

18 Laurenssen, E. M., Hutsebaut, J., Feenstra, D. J., Van Busschbach, J. J., & Luyten, P. (2013). Diagnosis of personality disorders in adolescents: a study among psychologists. Child and adolescent psychiatry and mental health, 7(1), 3. https://doi.org/10.1186/1753-2000-7-3

19 Paris (2013)

20 van Dijk, I., Krueger, R. F., & Laceulle, O. M. (2021). DSM-5 alternative personality disorder model traits as extreme variants of five-factor model traits in adolescents. Personality disorders, 12(1), 59–69. https://doi.org/10.1037/per0000409

21 Cicchetti et al. (2009)

22 Adshead et al. (2012)

23 Ibid. 

24 What are personality disorders?. Psychiatry.org - What are Personality Disorders? (2022, September). https://www.psychiatry.org/patients-families/personality-disorders/what-are-personality-disorders#:~:text=Diagnosis%20of%20a%20personality%20disorder,their%20personalities%20are%20still%20developing.

25 Ibid.

26 Ibid.

27 Adshead et al. (2012)

28 Ibid.

Alcohol & Anxiety: A Vicious Cycle

Comorbidity: Grounds for Investigation

Alcohol use and anxiety disorders are commonly comorbid, with alcoholics prone to experiencing symptoms of anxiety compared to the general population.[1] Schuckit & Hesselbrock (1994) report that 2 out of every 3 alcoholics possess the criteria to be diagnosed for another psychiatric disorder, such as anxiety.[2] There are explanations for both directions of the relationship, as people with anxiety may be using alcohol to feel better but alcohol could also lead to anxiety. In other words, anxiety disorders can cause alcohol abuse, and symptoms of anxiety are key aspects of alcohol dependence, particularly during withdrawal.[3] Although the etiology of the relationship between alcohol and anxiety is not clear, there is a link. Understanding the mechanisms behind the link between alcohol and the onset of anxiety can allow for the development of new solutions for stress and alcohol-related disorders. 

ADOLESCENTS AT RISK

Alcohol is the most commonly used drug among adolescents and this cohort is also more likely to experience alcohol abuse and dependence.[4] This is significant as adolescence is an important period in brain development during which critical regions of the brain (such as the prefrontal cortex (PFC), responsible for cognition and executive functioning) are still developing.[5] This process of brain development leaves adolescents vulnerable to psychological disorders such as anxiety, and drinking alcohol could exacerbate symptoms of anxiety and/or negatively affect brain development. 

UNDERSTANDING THE LINK

Several regions of the brain are implicated in the relationship between alcoholism and anxiety, particularly the PFC and the amygdala. The PFC relays information to the amygdala, which has important implications in pathologic behavior states.[6] The functional connectivity between the PFC and amygdala is crucial for several major psychological processes such as the regulation of emotions and stress. Hyperactivity and hyperreactivity of the amygdala are important measures of anxiety disorders. In particular, the central amygdala (CeA) is a primary component in the regulation of stress and anxiety. The CeA is the major output region in the amygdala and is part of the larger extended amygdala, a network of limbic forebrain structures, which is involved in the transition to alcohol dependence.[7] The CeA transforms emotional and sensory information into physiological and behavioral responses. Specifically, the signaling of the hormone corticotropin releasing factor (CRF) in the amygdala plays a significant role in anxiety as it is a prostress peptide, meaning it promotes anxiety-like behavior.[8,9] Injections of CRF into the amygdala lead to anxiety-like behaviors; therefore reducing levels of this hormone may alleviate anxiety.[10] Similarly, the CeA is a critical region involved in alcohol addiction and the negative reinforcement of alcohol abstinence.[11] Dysregulation of CRF signaling can therefore influence the development of alcoholism. 

Dysfunction in the amygdala is associated with both anxiety and substance abuse disorders. Acute and chronic exposure to alcohol have significant effects on synaptic transmission (signaling between neurons) in the amygdala, a key region of stress and anxiety circuitry.[12] This commonality of the involvement of the amygdala in both anxiety and alcoholism suggests a connection between the two disorders. Alcohol has been found to increase stress sensitivity from neurological changes in the amygdala.[13] For instance, CRF is a neuropeptide involved in the stress circuits that regulate anxiety associated with drug dependence. This hormone contributes to the regulation of anxiety and alcohol-related behaviors and thus plays an important role between anxiety and the neurological effects of alcohol consumption. A study by Silberman (2009) found that the release of CRF in the CeA increases in animals that are alcohol-dependent and contributes to anxiety resulting from alcohol-withdrawal.[14] This demonstrates that CRF is the mediating factor between dependence on alcohol and anxiety produced, as drinking alcohol increases the production of CRF in the amygdala, which consequently increases stress and anxiety. CRF plays a critical role in regulating negative affect and excessive alcohol drinking via the CeA.[15] Gilpen et al. (2012) found that binge drinking in dependent and non-dependent adolescent rats produces lasting neural and behavioral changes implicated in anxiety and alcohol use disorders.[16] 

IMPLICATIONS FOR SOLUTIONS

It would be beneficial for scientists to further examine the role of the amygdala in anxiety and alcohol consumption, especially in terms of seeking novel treatment options. Since anxiety is a key factor resulting from alcohol withdrawal that often leads to relapse, targeting this anxiety could prevent relapse. Pharmacologic approaches (e.g., developing drugs or medications that target CRF production) could alleviate the anxiety associated with alcohol consumption, which could help alcoholics recover rather than drinking more to alleviate anxiety; it could also prevent people from developing alcoholism by avoiding excessive drinking. Additionally, it could also prevent people from self-medicating their anxiety by consuming more alcohol. Targeting the prevention and reduction of withdrawal symptoms of alcohol consumption could be effective in treating alcoholism. 

Further, since adolescents are more vulnerable to developmental neurodegeneration (both in general but also from alcohol consumption) understanding the effects of alcohol on the brain in relation to anxiety could prevent impairments in functional brain activity and cognitive dysregulation.[17] This could benefit adolescents for the rest of their lives, as neurological changes from alcohol consumption that occur during adolescence have the potential to permanently impair their psychological abilities, thus hindering the ability to achieve their goals. 

If you or a friend/family member suspect you may have alcohol addiction, please reach out to a licensed mental health provider to discuss treatment options. 

Contributed by: Preeti Kota

Editor: Jennifer (Ghahari) Smith, Ph.D.

REFERENCES

1 Schuckit, M. & Hesselbrock, V. (1994). Alcohol dependence and Anxiety Disorders: What is the Relationship? The American Journal of Psychiatry, 151(12), 1723-1734. 

2 Ibid.

3 Gilpin, N., Herman, M., & Roberto, M. (2015). The Central Amygdala as an Integrative Hub for Anxiety and Alcohol Use Disorders. Biological Psychiatry, 77(10): 859-869. https://doi.org/10.1016/j.biopsych.2014.09.008

4 Witt, E. (2010). Research on alcohol and adolescent brain development: opportunities and future directions. Alcohol, 44(1): 119-124. https://doi.org/10.1016/j.alcohol.2009.08.011

5 Ibid.

6 Gilpin et al. (2015)

7 Ibid.

8 Ibid.

9 Silberman, Y. (2009). Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions. Alcohol, 43, 509-519. doi: 10.1016/j.alcohol.2009.01.002

10 Gray, T., & Bingaman, E. (1996). The amygdala: corticotropin-releasing factor, steroids, and stress. Critical Reviews in Neurobiology, 10(2):155-68. DOI: 10.1615/critrevneurobiol.v10.i2.10

11 Silberman (2009)

12 Ibid.

13 Gilpin et al. (2015)

14 Silberman (2009)

15 Gilpin et al. (2015)

16 Gilpin, N., Karanikas, C., & Richardson, H. (2012). Adolescent Binge Drinking Leads to Changes in Alcohol Drinking, Anxiety, and Amygdalar Corticotropin Releasing Factor Cells in Adulthood in Male Rats. PLoS ONE, 7(2): e31466. doi:10.1371/journal.pone.0031466

17 Zeigler, D., Wang, C., Yoast, R., Dickinson, B., McCaffree, M., Robinowitz, C., & Sterling, M. (2005). The neurocognitive effects of alcohol on adolescents and college students. Preventive Medicine, 40(1), 23-32. https://doi.org/10.1016/j.ypmed.2004.04.044